Four postdoctoral positions are available immediately to study chloride channel function in the context of human disease.  The laboratory is NIH funded to examine chloride channel contributions to secretion/function in pancreatic beta cells, neurons, and pulmonary macrophages in the context of diabetes, chronic lung infection and selective neuronal degeneration.  Mice lacking expression of the chloride channel ClC-3 show complete hippocampal degeneration over time in development as well as defective insulin secretion.  We are interested in determining the contribution of ClC-3 to synaptic vesicle as well as insulin granule acidification in vesicle priming for exocytosis.  We are seeking Ph.D. graduates with extensive training and a demonstrated publication record in one of the following areas: electrophysiology, molecular biology, protein purification/chemistry, live cell video microscopy, and/or chemical-protein interactions. To apply, please email your CV and three letters of recommendation to Deborah J. Nelson at nelson@uchicago.edu.